Business Opportunities

Chillicothe has around 9,500 residents and draws from a larger trade area in excess of 65,000. A “city in the country,” our north central Missouri community offers all the amenities and facilities of a larger city while maintaining the advantages of country life. Close to two major highways and served by a regional airport, it is a great place to do business.

With restaurants, shops, banks and even art galleries, downtown Chillicothe offers unique advantages to business owners. You can be part of a bustling retail and services center, and have everything that you need easily within reach.

If you need help starting out, contact Main Street Chillicothe. We can provide you with information about programs and incentives for new business owners or help you find a downtown location. We also have a new comprehensive business recruitment guide that provides information on funding sources, the contacts you need to start a business, Chillicothe's statistics, the vision for downtown, and more. Check it out here

Downtown by the Numbers

  • Total area of downtown: 0.25 square miles/40 city blocks
  • Total property value (market or insured value): $55.43 Million
  • Total downtown businesses: 165
  • Downtown is home to 33% of the business sector.
  • Total downtown employees: 1213
  • Downtown employs 20% of the city-wide workforce.
  • Total downtown residential population: 127
  • Logged over 3,000 volunteer hours annually totaling $59,900 in worth


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